Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years

Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years The evolution that took place between 1984 and 2011 in paediatric HIV infection in Gipuzkoa has been studied. The development of methods to diagnose the disease coupled with increasingly more effective treatments have made it possible to reduce mother-to-child transmission (vertical transmission) from 23.9% to 2.4%, thus virtually eradicating infection in children. via ScienceDaily: Top Health News: Nov. 29, 2013 — Miren Apilánez, researcher in the Department of pediatrics of the UPV/EHU-University of the Basque Country, has studied the evolution that took place between 1984 and 2011 in pediatric HIV infection in Gipuzkoa. The development of methods to diagnose the disease coupled with increasingly more effective treatments have made it possible to reduce mother-to-child transmission (vertical transmission) from 23.9% to 2.4%, thus virtually eradicating infection in children.Vertical transmission occurs between mothers infected with HIV and their offspring. This infection can take place at three different moments or phases: during pregnancy, during birth or during breastfeeding, “but in actual fact, the most critical moment is the birth because the child comes into contact with the mother’s blood or vaginal secretions,” explains the researcher. “Infection is also possible during pregnancy, but it is less likely because the placenta acts as a barrier.” As regards breastfeeding, “the moment it became known that it was a way of transmitting the infection, it was contraindicated in developed countries,” explains Apilánez.In the course of the research, Apilánez studied 239 children of HIV-infected mothers and born between 1984 and 2010 in Gipuzkoa, and their mothers. 30 children were infected by the virus, and 209 seroreverted during the first months of life.Four periods, four scenariosThroughout this time there is proof of an evolution in various aspects relating to the infection in Gipuzkoa: the transmission rate itself, the implementing of diagnostic and therapeutic methods in mothers and children, or the channel through which mothers acquire the HIV infection.So Apilánez has established four periods in the course of time, defined mainly by the implementing of diagnostic measures and therapies. The first period was the one between 1984, when the first child was diagnosed, until March 1994, and Apilánez defines it as “the period of few resources, characterized by the absence of effective therapies.”In March 1994 the results of the ACTG076 protocol were published worldwide showing that the administering of the first antiretroviral drug known as AZT during pregnancy and birth reduced vertical transmission considerably. The protocol stated that it had to be administered during pregnancy in order to improve the immunovirological situation of the mother, who would reach birth with an undetectable viral load and, therefore, with a minimal risk of passing the infection onto the child. The treatment is completed with intrapartum therapy as well as therapy for the newborn during the first 45 days. After starting this treatment in pregnant women infected with HIV in Gipuzkoa (second period), it was seen that within three years transmission fell from 25% to 8%. … For more info: Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years ScienceDaily: Top Health News Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years L’articolo Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years sembra essere il primo su My Biologica.

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Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years

Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years

The evolution that took place between 1984 and 2011 in paediatric HIV infection in Gipuzkoa has been studied. The development of methods to diagnose the disease coupled with increasingly more effective treatments have made it possible to reduce mother-to-child transmission (vertical transmission) from 23.9% to 2.4%, thus virtually eradicating infection in children.Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years

via ScienceDaily: Top Health News:

Nov. 29, 2013 — Miren Apilánez, researcher in the Department of pediatrics of the UPV/EHU-University of the Basque Country, has studied the evolution that took place between 1984 and 2011 in pediatric HIV infection in Gipuzkoa. The development of methods to diagnose the disease coupled with increasingly more effective treatments have made it possible to reduce mother-to-child transmission (vertical transmission) from 23.9% to 2.4%, thus virtually eradicating infection in children.Vertical transmission occurs between mothers infected with HIV and their offspring. This infection can take place at three different moments or phases: during pregnancy, during birth or during breastfeeding, “but in actual fact, the most critical moment is the birth because the child comes into contact with the mother’s blood or vaginal secretions,” explains the researcher. “Infection is also possible during pregnancy, but it is less likely because the placenta acts as a barrier.” As regards breastfeeding, “the moment it became known that it was a way of transmitting the infection, it was contraindicated in developed countries,” explains Apilánez.In the course of the research, Apilánez studied 239 children of HIV-infected mothers and born between 1984 and 2010 in Gipuzkoa, and their mothers. 30 children were infected by the virus, and 209 seroreverted during the first months of life.Four periods, four scenariosThroughout this time there is proof of an evolution in various aspects relating to the infection in Gipuzkoa: the transmission rate itself, the implementing of diagnostic and therapeutic methods in mothers and children, or the channel through which mothers acquire the HIV infection.So Apilánez has established four periods in the course of time, defined mainly by the implementing of diagnostic measures and therapies. The first period was the one between 1984, when the first child was diagnosed, until March 1994, and Apilánez defines it as “the period of few resources, characterized by the absence of effective therapies.”In March 1994 the results of the ACTG076 protocol were published worldwide showing that the administering of the first antiretroviral drug known as AZT during pregnancy and birth reduced vertical transmission considerably. The protocol stated that it had to be administered during pregnancy in order to improve the immunovirological situation of the mother, who would reach birth with an undetectable viral load and, therefore, with a minimal risk of passing the infection onto the child. The treatment is completed with intrapartum therapy as well as therapy for the newborn during the first 45 days. After starting this treatment in pregnant women infected with HIV in Gipuzkoa (second period), it was seen that within three years transmission fell from 25% to 8%. …

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Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years

L’articolo Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years sembra essere il primo su My Biologica.

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Mother-to-child HIV transmission in Gipuzkoa reduced significantly over last 25 years